Development of a novel bispecific antibody therapy to overcome myeloma heterogeneity

by Ehime UniversityMicrograph of a plasmacytoma, the histologic correlate of multiple myeloma. H&E stain. Credit: Wikipedia/CC BY-SA 3.0Multiple myeloma is still an incurable hematological ma

Updated on: March 25,2024

Development of a novel bispecific antibody therapy to overcome myeloma heterogeneity

by Ehime UniversityMicrograph of a plasmacytoma, the histologic correlate of multiple myeloma. H&E stain. Credit: Wikipedia/CC BY-SA 3.0Multiple myeloma is still an incurable hematological ma

Updated on:March 25,2024

Pancreatic cancer vaccine plus immunotherapy and antibody spark immune system response in pancreatic cancers

by Johns Hopkins University School of MedicineJ1568 study treatment schema.Eligible patients with clinically resectable PDA received the first priming study treatment Cy-GVAX-based therapy (alone

Updated on: January 30,2024

Pancreatic cancer vaccine plus immunotherapy and antibody spark immune system response in pancreatic cancers

by Johns Hopkins University School of MedicineJ1568 study treatment schema.Eligible patients with clinically resectable PDA received the first priming study treatment Cy-GVAX-based therapy (alone

Updated on:January 30,2024

Moderate exercise helps colorectal cancer patients live longer by reducing inflammation and improving gut bacteria

by Heather Simonsen,University of UtahCredit: Pixabay/CC0 Public DomainRegular physical activity can extend colorectal cancer patients' lives. In a first-ever study, scientists looked at the

Updated on: January 04,2024

Moderate exercise helps colorectal cancer patients live longer by reducing inflammation and improving gut bacteria

by Heather Simonsen,University of UtahCredit: Pixabay/CC0 Public DomainRegular physical activity can extend colorectal cancer patients' lives. In a first-ever study, scientists looked at the

Updated on:January 04,2024

Novel biomarker for immune checkpoint inhibitors identified in human lethal cancers

by Liu Jia,Chinese Academy of SciencesA model depicting how the SETD2 inactivation sensitizes cancer cells to immune checkpoint blockade through the NR2F1-STAT1 pathway. Credit: Prof. Wang Yuexi

Updated on: January 26,2024

Novel biomarker for immune checkpoint inhibitors identified in human lethal cancers

by Liu Jia,Chinese Academy of SciencesA model depicting how the SETD2 inactivation sensitizes cancer cells to immune checkpoint blockade through the NR2F1-STAT1 pathway. Credit: Prof. Wang Yuexi

Updated on:January 26,2024

Novel late-stage colorectal cancer treatment proves effective in preclinical models

by Angel Mendez,University of Minnesota Medical SchoolThe low T cells are due to exosomal, immunosuppressive miRNAs that disrupt T cell function and loss of T cells in the tumor environment. Cre

Updated on: April 29,2024

Novel late-stage colorectal cancer treatment proves effective in preclinical models

by Angel Mendez,University of Minnesota Medical SchoolThe low T cells are due to exosomal, immunosuppressive miRNAs that disrupt T cell function and loss of T cells in the tumor environment. Cre

Updated on:April 29,2024

Researchers unlock mysteries of complex microRNA oncogenes

by McGill UniversityMicroRNA and mRNA visualization in differentiating C1C12 cells. Credit: Ryan Jeffs/WikipediaMicroRNAs are tiny molecules of nucleic acid that control gene expression, acting l

Updated on: June 11,2024

Researchers unlock mysteries of complex microRNA oncogenes

by McGill UniversityMicroRNA and mRNA visualization in differentiating C1C12 cells. Credit: Ryan Jeffs/WikipediaMicroRNAs are tiny molecules of nucleic acid that control gene expression, acting l

Updated on:June 11,2024

Keeping aggressive cancer cells in check by blocking a protein responsible for repairs

by Catarina Pietschmann,Max Delbrück Center for Molecular MedicineThree-dimensional culture of human breast cancer cells, with DNA stained blue and a protein in the cell surface membrane stained

Updated on: January 07,2024

Keeping aggressive cancer cells in check by blocking a protein responsible for repairs

by Catarina Pietschmann,Max Delbrück Center for Molecular MedicineThree-dimensional culture of human breast cancer cells, with DNA stained blue and a protein in the cell surface membrane stained

Updated on:January 07,2024

Trial shows improvements in several clinical outcomes for men with intermediate-risk prostate cancer

by NRG OncologyCredit: Unsplash/CC0 Public DomainResults from the phase 3 NRG Oncology RTOG 0815 clinical study comparing dose-escalated radiotherapy (RT) alone to dose-escalated RT with short-term an

Updated on: January 04,2024

Trial shows improvements in several clinical outcomes for men with intermediate-risk prostate cancer

by NRG OncologyCredit: Unsplash/CC0 Public DomainResults from the phase 3 NRG Oncology RTOG 0815 clinical study comparing dose-escalated radiotherapy (RT) alone to dose-escalated RT with short-term an

Updated on:January 04,2024

CAR T cell immunotherapy for solid tumors? First, you have to break the cancers' sugar shield

by Delthia Ricks , Medical XpressModeling of the impact of tumor N-glycans on the targeting by CAR T cells. Left, the N-glycan decoration of tumors 1) repels CAR T cells by impeding immunological syna

Updated on: April 09,2024

CAR T cell immunotherapy for solid tumors? First, you have to break the cancers' sugar shield

by Delthia Ricks , Medical XpressModeling of the impact of tumor N-glycans on the targeting by CAR T cells. Left, the N-glycan decoration of tumors 1) repels CAR T cells by impeding immunological syna

Updated on:April 09,2024

Researchers report results in rare gynecologic cancers from DART immunotherapy trial

by SWOG Cancer Research NetworkCredit: Unsplash/CC0 Public DomainResults from the S1609 DART clinical trial, which tested an immunotherapy combination of ipilimumab plus nivolumab in 53 cohorts of pat

Updated on: February 03,2024

Researchers report results in rare gynecologic cancers from DART immunotherapy trial

by SWOG Cancer Research NetworkCredit: Unsplash/CC0 Public DomainResults from the S1609 DART clinical trial, which tested an immunotherapy combination of ipilimumab plus nivolumab in 53 cohorts of pat

Updated on:February 03,2024

PSA levels after treatment may not be reliable predictor of survival for patients with prostate cancer

by University of California, Los AngelesCredit: Unsplash/CC0 Public DomainA UCLA-led study has found treatments that reduce the risk of being diagnosed with a cancer recurrence based on rising pr

Updated on: February 18,2024

PSA levels after treatment may not be reliable predictor of survival for patients with prostate cancer

by University of California, Los AngelesCredit: Unsplash/CC0 Public DomainA UCLA-led study has found treatments that reduce the risk of being diagnosed with a cancer recurrence based on rising pr

Updated on:February 18,2024

Muscle wasting severity linked to type, size and location of tumor in mice

byPennsylvania State UniversitySkeletal muscle fibers. Credit: Berkshire Community College Bioscience Image Library / Public domainAbout 80% of people with cancer suffer from significant muscle

Updated on: January 11,2024

Muscle wasting severity linked to type, size and location of tumor in mice

byPennsylvania State UniversitySkeletal muscle fibers. Credit: Berkshire Community College Bioscience Image Library / Public domainAbout 80% of people with cancer suffer from significant muscle

Updated on:January 11,2024