Research finds unexpected link between chromosomal instability and epigenetic alterations

by Ian Demsky,Memorial Sloan Kettering Cancer CenterThe two colored dots outside of this breast cancer cell's primary nucleus indicate the presence of micronuclei. A new study investigated h

Updated on: January 29,2024

Research finds unexpected link between chromosomal instability and epigenetic alterations

by Ian Demsky,Memorial Sloan Kettering Cancer CenterThe two colored dots outside of this breast cancer cell's primary nucleus indicate the presence of micronuclei. A new study investigated h

Updated on:January 29,2024

Drug combination provides a one-two punch attack against colorectal cancer

by National Cancer InstituteOn the left,SN38, the active metabolite of irinotecan, traps TOP1 on DNA, forming TOP1 cleavage complexes that are degraded upon their formation, as seen by the

Updated on: January 29,2024

Drug combination provides a one-two punch attack against colorectal cancer

by National Cancer InstituteOn the left,SN38, the active metabolite of irinotecan, traps TOP1 on DNA, forming TOP1 cleavage complexes that are degraded upon their formation, as seen by the

Updated on:January 29,2024

Soluble immune checkpoint factors in blood as potential biomarkers of therapeutic efficacy for ICI cancer immunotherapy

by Kindai UniversityThe concentration of soluble PD-L1m PD-1, CTLA4 in plasma were highly correlated with the expression of genes associated with exhaustion in the peripheral CD8+T cells. R valu

Updated on: April 06,2024

Soluble immune checkpoint factors in blood as potential biomarkers of therapeutic efficacy for ICI cancer immunotherapy

by Kindai UniversityThe concentration of soluble PD-L1m PD-1, CTLA4 in plasma were highly correlated with the expression of genes associated with exhaustion in the peripheral CD8+T cells. R valu

Updated on:April 06,2024

Novel inherited variants may raise risk for Hodgkin lymphoma

Novel coding and noncoding gene variants have been identified that may increase the risk for developing Hodgkin lymphoma (HL), according to a study published online Aug. 20 inBlood.Jamie E. Fler

Updated on: January 13,2024

Novel inherited variants may raise risk for Hodgkin lymphoma

Novel coding and noncoding gene variants have been identified that may increase the risk for developing Hodgkin lymphoma (HL), according to a study published online Aug. 20 inBlood.Jamie E. Fler

Updated on:January 13,2024

Preclinical study shows promise of systemic targeted therapy in a rare form of cancer

byVall d'Hebron Institute of OncologyTreatment with BRAF inhibitors reduces tumor cell proliferation in subcutaneous BRAFV600EPMP-PDX tumors without impacting in apoptosis. a–d) Mice b

Updated on: August 03,2024

Preclinical study shows promise of systemic targeted therapy in a rare form of cancer

byVall d'Hebron Institute of OncologyTreatment with BRAF inhibitors reduces tumor cell proliferation in subcutaneous BRAFV600EPMP-PDX tumors without impacting in apoptosis. a–d) Mice b

Updated on:August 03,2024

How metastatic cancer causes leaky blood vessels

byAmerican Institute of PhysicsImmunofluorescence images showing the effects of contactless paracrine signaling interactions (left) or physical contact (right) in micropatterned endothelial cell

Updated on: January 22,2024

How metastatic cancer causes leaky blood vessels

byAmerican Institute of PhysicsImmunofluorescence images showing the effects of contactless paracrine signaling interactions (left) or physical contact (right) in micropatterned endothelial cell

Updated on:January 22,2024

New alveolar soft-part sarcoma chip can mimic the microenvironment during angiogenesis

by Kyoto UniversityAngiogenic microenvironment of alveolar soft-part sarcoma (ASPS) in a microfluidic chip. Credit: KyotoU/Ryuji YokokawaCancer, the second leading cause of death worldwide, is mo

Updated on: March 30,2024

New alveolar soft-part sarcoma chip can mimic the microenvironment during angiogenesis

by Kyoto UniversityAngiogenic microenvironment of alveolar soft-part sarcoma (ASPS) in a microfluidic chip. Credit: KyotoU/Ryuji YokokawaCancer, the second leading cause of death worldwide, is mo

Updated on:March 30,2024

Prostate cancer: Getting ever closer to diagnosis using an 'electronic nose'

by Politecnico di MilanoPrototype of an electronic nose developed by the Politecnico di Milano in partnership with Humanitas, capable of diagnosing a tumor using a urine sample with 82% accuracy. Cred

Updated on: January 02,2024

Prostate cancer: Getting ever closer to diagnosis using an 'electronic nose'

by Politecnico di MilanoPrototype of an electronic nose developed by the Politecnico di Milano in partnership with Humanitas, capable of diagnosing a tumor using a urine sample with 82% accuracy. Cred

Updated on:January 02,2024

New treatments, screening methods dramatically reduce breast cancer deaths, study finds

by Stanford University Medical CenterMammograms showing a normal breast (left) and a breast with cancer (right). Credit: Public DomainIn the last few decades, dozens of new breast cancer drugs—fr

Updated on: March 01,2024

New treatments, screening methods dramatically reduce breast cancer deaths, study finds

by Stanford University Medical CenterMammograms showing a normal breast (left) and a breast with cancer (right). Credit: Public DomainIn the last few decades, dozens of new breast cancer drugs—fr

Updated on:March 01,2024

Researchers uncovers promising cancer target for liposarcoma

by National University of SingaporeCredit: CC0 Public DomainA study conducted by a team of researchers from the Cancer Science Institute of Singapore (CSI Singapore) at the National University of

Updated on: June 19,2024

Researchers uncovers promising cancer target for liposarcoma

by National University of SingaporeCredit: CC0 Public DomainA study conducted by a team of researchers from the Cancer Science Institute of Singapore (CSI Singapore) at the National University of

Updated on:June 19,2024

Researchers find changes in blood proteins up to two years before breast cancer diagnosis

by European Organisation for Research and Treatment of CancerCredit: Pixabay/CC0 Public DomainResearchers have found changes in the levels of particular proteins in people's blood up to two years

Updated on: January 30,2024

Researchers find changes in blood proteins up to two years before breast cancer diagnosis

by European Organisation for Research and Treatment of CancerCredit: Pixabay/CC0 Public DomainResearchers have found changes in the levels of particular proteins in people's blood up to two years

Updated on:January 30,2024

Blocking a key immune protein improves radiation therapy for cancer

byUniversity of ChicagoCredit: Unsplash/CC0 Public DomainUp to 60% of cancer patients receive radiation therapy, but it doesn't always work. Failure of these treatments results from tumor re

Updated on: January 22,2024

Blocking a key immune protein improves radiation therapy for cancer

byUniversity of ChicagoCredit: Unsplash/CC0 Public DomainUp to 60% of cancer patients receive radiation therapy, but it doesn't always work. Failure of these treatments results from tumor re

Updated on:January 22,2024