Scientists develop first bone marrow model that supports human stem cells

byUniversity of GlasgowSchematic of the bone marrow (BM) niche microenvironment. Credit:Nature Communications(2024). DOI: 10.1038/s41467-024-50054-0Scientists have created the first

Updated on: August 03,2024

Scientists develop first bone marrow model that supports human stem cells

byUniversity of GlasgowSchematic of the bone marrow (BM) niche microenvironment. Credit:Nature Communications(2024). DOI: 10.1038/s41467-024-50054-0Scientists have created the first

Updated on:August 03,2024

Scientists discover how air pollution triggers lung cancer

Credit: Pixabay/CC0 Public DomainScientists said Saturday they had identified the mechanism through which air pollution triggers lung cancer in non-smokers, a discovery one expert hailed as "an i

Updated on: December 27,2023

Scientists discover how air pollution triggers lung cancer

Credit: Pixabay/CC0 Public DomainScientists said Saturday they had identified the mechanism through which air pollution triggers lung cancer in non-smokers, a discovery one expert hailed as "an i

Updated on:December 27,2023

New clue discovered as to how and why cancer cells spread

by Gillian Rutherford,University of AlbertaViscosity enhances cell migration and promotes an ARP2/3-mediated dense actin network at the leading edge.a,b, Speeds of MDA-MB-231 cells (a) and

Updated on: December 22,2023

New clue discovered as to how and why cancer cells spread

by Gillian Rutherford,University of AlbertaViscosity enhances cell migration and promotes an ARP2/3-mediated dense actin network at the leading edge.a,b, Speeds of MDA-MB-231 cells (a) and

Updated on:December 22,2023

Researchers elucidate roles of TP63 and SOX2 in squamous cell cancer progression

byNational University of SingaporeCredit: CC0 Public DomainSquamous cell carcinomas (SCCs) are aggressive malignancies arising from the squamous epithelium of various organs, such as the esophag

Updated on: December 18,2023

Researchers elucidate roles of TP63 and SOX2 in squamous cell cancer progression

byNational University of SingaporeCredit: CC0 Public DomainSquamous cell carcinomas (SCCs) are aggressive malignancies arising from the squamous epithelium of various organs, such as the esophag

Updated on:December 18,2023

Relapse Following CAR T-cell Therapy Linked to Poor OS in Relapsed/Refractory Myeloma

August 27, 2022Lisa AstorRelapse following treatment with BCMA-directed CAR T-cell therapy was associated with poor survival outcomes in patients with relapsed/refractory multiple myeloma.Multiple Mye

Updated on: October 24,2023

Relapse Following CAR T-cell Therapy Linked to Poor OS in Relapsed/Refractory Myeloma

August 27, 2022Lisa AstorRelapse following treatment with BCMA-directed CAR T-cell therapy was associated with poor survival outcomes in patients with relapsed/refractory multiple myeloma.Multiple Mye

Updated on:October 24,2023

Overexpressed Cyclin D1 and CDK4 proteins are responsible for the resistance to CDK4/6 inhibitor in some breast cancer

byScience China PressThe CDK4/6 inhibitors-resistant breast cancer cells expressed more Cyclin D1 and CDK4 proteins than the parental cells (Upper left). PI3K pathway was hyper-activated in the

Updated on: December 23,2023

Overexpressed Cyclin D1 and CDK4 proteins are responsible for the resistance to CDK4/6 inhibitor in some breast cancer

byScience China PressThe CDK4/6 inhibitors-resistant breast cancer cells expressed more Cyclin D1 and CDK4 proteins than the parental cells (Upper left). PI3K pathway was hyper-activated in the

Updated on:December 23,2023

Ultrafine particles can change defense against lung cancer

by Graciela Gutierrez,Baylor College of MedicinenCB accelerates NSCLC development and metastasis in mice. (A) Schematic diagram of nCB exposure in Pts4d/dmice. Three-month-old Pts4d/d&nbsp

Updated on: December 19,2023

Ultrafine particles can change defense against lung cancer

by Graciela Gutierrez,Baylor College of MedicinenCB accelerates NSCLC development and metastasis in mice. (A) Schematic diagram of nCB exposure in Pts4d/dmice. Three-month-old Pts4d/d&nbsp

Updated on:December 19,2023

Curbing blood cancers by teaching immune cells to kill mutant stem cells

by Nancy Fliesler,Children's Hospital BostonROS and TLR3 signaling mediates the "eat-me" and "don't eat me" signals that determine stem cell clonal selection by macro

Updated on: October 24,2024

Curbing blood cancers by teaching immune cells to kill mutant stem cells

by Nancy Fliesler,Children's Hospital BostonROS and TLR3 signaling mediates the "eat-me" and "don't eat me" signals that determine stem cell clonal selection by macro

Updated on:October 24,2024

Researchers find the key to genome-modifying drugs' sensitivity in malignant blood diseases

by Josep Carreras Leukaemia Research InstituteImpact of azacitidine on global DNA methylation patterns and definition of EPIAZA signature in patients with MDS. (A) Study design and workflow. (B,

Updated on: March 20,2024

Researchers find the key to genome-modifying drugs' sensitivity in malignant blood diseases

by Josep Carreras Leukaemia Research InstituteImpact of azacitidine on global DNA methylation patterns and definition of EPIAZA signature in patients with MDS. (A) Study design and workflow. (B,

Updated on:March 20,2024

Acid reflux drugs may have negative side effects for breast cancer survivors

by Emily Caldwell,The Ohio State UniversityAcid reflux drugs that are sometimes recommended to ease stomach problems during cancer treatment may have an unintended side effect: impairment of bre

Updated on: December 23,2023

Acid reflux drugs may have negative side effects for breast cancer survivors

by Emily Caldwell,The Ohio State UniversityAcid reflux drugs that are sometimes recommended to ease stomach problems during cancer treatment may have an unintended side effect: impairment of bre

Updated on:December 23,2023

Scientists reveal a potential new approach to treating liver cancer

byNational Institutes of Healtha, Schematic of drug screening and validation studies; MoA, mechanism of action.b, Graphs of the results from the small-molecule screen with the MIPE library

Updated on: December 27,2023

Scientists reveal a potential new approach to treating liver cancer

byNational Institutes of Healtha, Schematic of drug screening and validation studies; MoA, mechanism of action.b, Graphs of the results from the small-molecule screen with the MIPE library

Updated on:December 27,2023

Single-cell 'atlas' reveals origin of an aggressive brain tumor

byCincinnati Children's Hospital Medical CenterChartshows that mice with reduced activity of either the SOX11 or HNRNOH1 genes had longer survival times when induced to develop medullo

Updated on: December 20,2023

Single-cell 'atlas' reveals origin of an aggressive brain tumor

byCincinnati Children's Hospital Medical CenterChartshows that mice with reduced activity of either the SOX11 or HNRNOH1 genes had longer survival times when induced to develop medullo

Updated on:December 20,2023