Shades of grey reveal breast tumours

by David Bradley,InderscienceMammograms showing a normal breast (left) and a breast with cancer (right). Credit: Public DomainBreast cancer is the second most common cancer in women. Mammography

Updated on: March 01,2024

Shades of grey reveal breast tumours

by David Bradley,InderscienceMammograms showing a normal breast (left) and a breast with cancer (right). Credit: Public DomainBreast cancer is the second most common cancer in women. Mammography

Updated on:March 01,2024

Two for the price of one: Mechanistic insights lead to drug repositioning

by University of TsukubaMolecular mechanism at a glance. SFN binds with SKP1 to sequester it in cytoplasm,resulting in the obstruction of SCFFBW7 598 complex formation. Oncoproteins including cyc

Updated on: May 23,2024

Two for the price of one: Mechanistic insights lead to drug repositioning

by University of TsukubaMolecular mechanism at a glance. SFN binds with SKP1 to sequester it in cytoplasm,resulting in the obstruction of SCFFBW7 598 complex formation. Oncoproteins including cyc

Updated on:May 23,2024

Study shows improved outcomes in hospitals accredited for rectal cancer surgery

byAmerican College of SurgeonsCredit: Pixabay/CC0 Public DomainHospitals accredited by the American College of Surgeons (ACS) National Accreditation Program for Rectal Cancer (NAPRC) demonstrate

Updated on: March 30,2024

Study shows improved outcomes in hospitals accredited for rectal cancer surgery

byAmerican College of SurgeonsCredit: Pixabay/CC0 Public DomainHospitals accredited by the American College of Surgeons (ACS) National Accreditation Program for Rectal Cancer (NAPRC) demonstrate

Updated on:March 30,2024

Molecular change to immunotherapy antibody could accelerate immune response to cancer

byWeizmann Institute of ScienceTissue sample of a particularly aggressive skin cancer reveals immune cells (yellow) that express on their surfaces a “brake pedal” receptor called FcgIIb (purple)

Updated on: January 02,2024

Molecular change to immunotherapy antibody could accelerate immune response to cancer

byWeizmann Institute of ScienceTissue sample of a particularly aggressive skin cancer reveals immune cells (yellow) that express on their surfaces a “brake pedal” receptor called FcgIIb (purple)

Updated on:January 02,2024

Study: Drugs reprogram genes in breast tumors to prevent endocrine resistance

by Sharita Forrest,University of Illinois at Urbana-ChampaignTargeting estrogen receptor-positive breast tumors with the XPO1 antagonist selinexor and the tamoxifen byproduct 4-OHT simultaneousl

Updated on: May 27,2024

Study: Drugs reprogram genes in breast tumors to prevent endocrine resistance

by Sharita Forrest,University of Illinois at Urbana-ChampaignTargeting estrogen receptor-positive breast tumors with the XPO1 antagonist selinexor and the tamoxifen byproduct 4-OHT simultaneousl

Updated on:May 27,2024

3-D scaffold map to help the search for new cancer treatments

by Walter and Eliza Hall Institute of Medical ResearchScientists have solved the 3-D structure of molecular scaffold SgK223, which is known to play a critical role in the development and spread o

Updated on: March 14,2024

3-D scaffold map to help the search for new cancer treatments

by Walter and Eliza Hall Institute of Medical ResearchScientists have solved the 3-D structure of molecular scaffold SgK223, which is known to play a critical role in the development and spread o

Updated on:March 14,2024

Novel AI tools tackle soft tissue sarcomas, identify new treatment strategies

byStanford University Medical CenterA machine-learning framework for large-scale identification and validation of sarcoma cell states and ecosystems. Credit:Nature Cancer(2024). DOI:

Updated on: March 30,2024

Novel AI tools tackle soft tissue sarcomas, identify new treatment strategies

byStanford University Medical CenterA machine-learning framework for large-scale identification and validation of sarcoma cell states and ecosystems. Credit:Nature Cancer(2024). DOI:

Updated on:March 30,2024

Deep proteomic profiling reveals possible therapeutic targets for medulloblastoma

byTranslational Genomics Research InstituteSample overview and subgroup classification. (A) Common molecular alterations and subgroup classifications of 20 MB PDX models. (B) Partial least squar

Updated on: January 04,2024

Deep proteomic profiling reveals possible therapeutic targets for medulloblastoma

byTranslational Genomics Research InstituteSample overview and subgroup classification. (A) Common molecular alterations and subgroup classifications of 20 MB PDX models. (B) Partial least squar

Updated on:January 04,2024

Link between sphingolipids and complement signaling may be key to stopping cancer metastasis

by Caroline Wallace,Medical University of South CarolinaGraphical Abstract. Credit:Cell Reports(2022). DOI: 10.1016/j.celrep.2022.111742MUSC Hollings Cancer Center researchers have i

Updated on: January 02,2024

Link between sphingolipids and complement signaling may be key to stopping cancer metastasis

by Caroline Wallace,Medical University of South CarolinaGraphical Abstract. Credit:Cell Reports(2022). DOI: 10.1016/j.celrep.2022.111742MUSC Hollings Cancer Center researchers have i

Updated on:January 02,2024

New research casts doubt on role of fungus in driving pancreatic cancer

byDuke University Medical CenterAxial CT image with i.v. contrast. Macrocystic adenocarcinoma of the pancreatic head. Credit: public domainFour years ago, a report that a common species of fungu

Updated on: January 12,2024

New research casts doubt on role of fungus in driving pancreatic cancer

byDuke University Medical CenterAxial CT image with i.v. contrast. Macrocystic adenocarcinoma of the pancreatic head. Credit: public domainFour years ago, a report that a common species of fungu

Updated on:January 12,2024

Researchers find possible cause for chemoresistance in bowel cancer

by Martin-Luther-Universität Halle-WittenbergAnalysis of IGF2BP2 targets in tumor and metastatic CRC tissues. A, B Cumulative plot of gene expression (log2 fold change) in primary (A) and metastatic (

Updated on: January 30,2024

Researchers find possible cause for chemoresistance in bowel cancer

by Martin-Luther-Universität Halle-WittenbergAnalysis of IGF2BP2 targets in tumor and metastatic CRC tissues. A, B Cumulative plot of gene expression (log2 fold change) in primary (A) and metastatic (

Updated on:January 30,2024

Family of DNA damage–inducing microbial metabolites found in guts of people with IBD

by Bob Yirka , Medical XpressHuman gut microbes isolated from IBD patients produce small-molecule genotoxins. Diverse gut microbes isolated from patients with IBD exhibit direct genotoxicity. M. morga

Updated on: February 03,2024

Family of DNA damage–inducing microbial metabolites found in guts of people with IBD

by Bob Yirka , Medical XpressHuman gut microbes isolated from IBD patients produce small-molecule genotoxins. Diverse gut microbes isolated from patients with IBD exhibit direct genotoxicity. M. morga

Updated on:February 03,2024