Chronic lactate exposure leads to cellular disruptions implicated in cancer and possibly T2 diabetes

by CU Anschutz Medical CampusCredit: CC0 Public DomainAcute amounts of lactate like those generated during exercise are probably required for healthy cells, but chronic exposure causes cellular d

Updated on: February 05,2024

Chronic lactate exposure leads to cellular disruptions implicated in cancer and possibly T2 diabetes

by CU Anschutz Medical CampusCredit: CC0 Public DomainAcute amounts of lactate like those generated during exercise are probably required for healthy cells, but chronic exposure causes cellular d

Updated on:February 05,2024

Inhibiting production of a key material biosynthesis to slow tumor growth

by Will Doss,Northwestern UniversitySAM inhibitor drastically reduced cancer growth in models of human cancer. Credit: Northwestern UniversityMany cancers hijack a metabolic mechanism known as t

Updated on: February 21,2024

Inhibiting production of a key material biosynthesis to slow tumor growth

by Will Doss,Northwestern UniversitySAM inhibitor drastically reduced cancer growth in models of human cancer. Credit: Northwestern UniversityMany cancers hijack a metabolic mechanism known as t

Updated on:February 21,2024

Removing a protein could prevent aging and obesity from evolving into metabolic diseases, research suggests

byUniversity of CopenhagenThe ribotoxic stress response drives metabolic maladaptation in obesity and aging. ROS are a physiologically relevant source of translational impairment and activation

Updated on: January 18,2024

Removing a protein could prevent aging and obesity from evolving into metabolic diseases, research suggests

byUniversity of CopenhagenThe ribotoxic stress response drives metabolic maladaptation in obesity and aging. ROS are a physiologically relevant source of translational impairment and activation

Updated on:January 18,2024

Discovery could help reduce adverse side effects of popular next-generation obesity medications

byMonell Chemical Senses CenterActivating GLP1 receptor-expressing neurons in the nucleus tractus solitarius (magenta) increase sateity without causing nausea or aversion. Credit: Alisha Acosta,

Updated on: July 11,2024

Discovery could help reduce adverse side effects of popular next-generation obesity medications

byMonell Chemical Senses CenterActivating GLP1 receptor-expressing neurons in the nucleus tractus solitarius (magenta) increase sateity without causing nausea or aversion. Credit: Alisha Acosta,

Updated on:July 11,2024

Lifestyle may counter genetic risk for thyroid cancer

by Lori Solomon HealthDay ReporterGenetic and lifestyle factors are independently associated with incident thyroid cancer, according to a study published online Dec. 12 inJAMA Network Open.Xiumi

Updated on: February 21,2024

Lifestyle may counter genetic risk for thyroid cancer

by Lori Solomon HealthDay ReporterGenetic and lifestyle factors are independently associated with incident thyroid cancer, according to a study published online Dec. 12 inJAMA Network Open.Xiumi

Updated on:February 21,2024

Scientists discover roles of hypothalamic amino acid sensing in antidepressant effects

by Higher Education PressDeprivation of an essential amino acid leucine exhibits antidepressant effects under chronic stress by stimulating GCN2 and neural activity in AgRP neurons. Credit: Feixiang Y

Updated on: February 03,2024

Scientists discover roles of hypothalamic amino acid sensing in antidepressant effects

by Higher Education PressDeprivation of an essential amino acid leucine exhibits antidepressant effects under chronic stress by stimulating GCN2 and neural activity in AgRP neurons. Credit: Feixiang Y

Updated on:February 03,2024

Research team may have found the key to stimulating human brown adipose tissue into combating obesity

byUniversity of California, Los AngelesCredit: CC0 Public DomainA UCLA-led team of researchers has found nerve pathways that supply brown adipose tissue (BAT), a type of tissue that releases che

Updated on: January 20,2024

Research team may have found the key to stimulating human brown adipose tissue into combating obesity

byUniversity of California, Los AngelesCredit: CC0 Public DomainA UCLA-led team of researchers has found nerve pathways that supply brown adipose tissue (BAT), a type of tissue that releases che

Updated on:January 20,2024

Mouse study: A neural circuit for the suppression of feeding under persistent pain

by Bob Yirka , Medical XpressCredit: Pixabay/CC0 Public DomainA team of researchers from the University of Science and Technology of China and The Second Affiliated Hospital of Anhui Medical Universit

Updated on: February 21,2024

Mouse study: A neural circuit for the suppression of feeding under persistent pain

by Bob Yirka , Medical XpressCredit: Pixabay/CC0 Public DomainA team of researchers from the University of Science and Technology of China and The Second Affiliated Hospital of Anhui Medical Universit

Updated on:February 21,2024

Scientific review suggests even normal-weight individuals are susceptible to severe fatty liver disease

by The Translational Genomics Research InstitutePotential contributors to NAFLD in lean individuals. Despite the same pathological findings in the liver, the factors that contribute to NAFLD and

Updated on: February 05,2024

Scientific review suggests even normal-weight individuals are susceptible to severe fatty liver disease

by The Translational Genomics Research InstitutePotential contributors to NAFLD in lean individuals. Despite the same pathological findings in the liver, the factors that contribute to NAFLD and

Updated on:February 05,2024

Reducing stress on T cells makes them better cancer fighters

bySalk InstituteExhausted killer T cells with higher expression of the noradrenaline receptor ADRB1 (cyan) surround sympathetic nerves (yellow) in a virally infected spleen. Killer T cells witho

Updated on: January 20,2024

Reducing stress on T cells makes them better cancer fighters

bySalk InstituteExhausted killer T cells with higher expression of the noradrenaline receptor ADRB1 (cyan) surround sympathetic nerves (yellow) in a virally infected spleen. Killer T cells witho

Updated on:January 20,2024

Researchers reveal how diabetes weakens gum defense

by Pusan National UniversityThe study associating periodontitis (PD) and diabetes mellitus (DM) using single-cell RNA analysis offers the first immunological explanation, revealing altered immune

Updated on: March 14,2024

Researchers reveal how diabetes weakens gum defense

by Pusan National UniversityThe study associating periodontitis (PD) and diabetes mellitus (DM) using single-cell RNA analysis offers the first immunological explanation, revealing altered immune

Updated on:March 14,2024

Decreasing sedentary time in class found to reduce obesity in children

by University College LondonCredit: Unsplash/CC0 Public DomainIntroducing more movement into lessons led to an 8% reduction in children's waist-to-height ratio, according to new research from

Updated on: March 13,2024

Decreasing sedentary time in class found to reduce obesity in children

by University College LondonCredit: Unsplash/CC0 Public DomainIntroducing more movement into lessons led to an 8% reduction in children's waist-to-height ratio, according to new research from

Updated on:March 13,2024