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Breakthroughs
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US company withdraws ALS drug after it fails in trial

US company withdraws ALS drug after it fails in trial

An MRI with increased signal in the posterior part of the internal capsule which can be tracked to the motor cortex consistent with the diagnosis of ALS. Credit: Frank Gaillard/WikipediaAmylyx Pharmac

US company withdraws ALS drug after it fails in trial

An MRI with increased signal in the posterior part of the internal capsule which can be tracked to the motor cortex consistent with the diagnosis of ALS. Credit: Frank Gaillard/WikipediaAmylyx Pharmac
Alarm over lax oversight of weight loss drug adverts that could harm patients

Alarm over lax oversight of weight loss drug adverts that could harm patients

byBritish Medical JournalCredit: Unsplash/CC0 Public DomainUK organizations responsible for protecting the public from prescription-only drug adverts are putting patients at risk from the harms

Alarm over lax oversight of weight loss drug adverts that could harm patients

byBritish Medical JournalCredit: Unsplash/CC0 Public DomainUK organizations responsible for protecting the public from prescription-only drug adverts are putting patients at risk from the harms
Researchers identify a potential target for reversing poor metabolic traits

Researchers identify a potential target for reversing poor metabolic traits

by Brandon Chase,Massachusetts General HospitalGraphical abstract. Credit:Cell Metabolism(2023). DOI: 10.1016/j.cmet.2023.11.010During oxidative stress, excess production of reactive

Researchers identify a potential target for reversing poor metabolic traits

by Brandon Chase,Massachusetts General HospitalGraphical abstract. Credit:Cell Metabolism(2023). DOI: 10.1016/j.cmet.2023.11.010During oxidative stress, excess production of reactive
West Virginia city once battered by opioid overdoses confronts 'fourth wave'

West Virginia city once battered by opioid overdoses confronts 'fourth wave'

by Taylor Sisk, KFF Health NewsCredit: CC0 Public DomainFrom 2006 through 2014, more than 81 million painkiller pills were shipped to this city and surrounding rural Cabell County.The arrival of presc

West Virginia city once battered by opioid overdoses confronts 'fourth wave'

by Taylor Sisk, KFF Health NewsCredit: CC0 Public DomainFrom 2006 through 2014, more than 81 million painkiller pills were shipped to this city and surrounding rural Cabell County.The arrival of presc
Why clinical trials stop: Researchers find a link between genetic evidence and trial outcome

Why clinical trials stop: Researchers find a link between genetic evidence and trial outcome

by Helena Cornu,European Molecular Biology LaboratoryHierarchical clustering of stop reason similarity based on curation from Pak et al. and 447 additional stopped trials due to COVID-19. Credit

Why clinical trials stop: Researchers find a link between genetic evidence and trial outcome

by Helena Cornu,European Molecular Biology LaboratoryHierarchical clustering of stop reason similarity based on curation from Pak et al. and 447 additional stopped trials due to COVID-19. Credit
Mouse study successfully regenerates thyroid glands in the spleen

Mouse study successfully regenerates thyroid glands in the spleen

by Nanjing University School of Life SciencesSchematic description of intra-splenic thyroid regeneration (left) and staining images of reconstructed thyroid tissues within the spleen (right). Credit:

Mouse study successfully regenerates thyroid glands in the spleen

by Nanjing University School of Life SciencesSchematic description of intra-splenic thyroid regeneration (left) and staining images of reconstructed thyroid tissues within the spleen (right). Credit:
Researchers identify and manipulate neural circuits for risk/reward decision-making in primates

Researchers identify and manipulate neural circuits for risk/reward decision-making in primates

by Spyros Goulas, Institute for the Advanced Study of Human Biology (ASHBI)Bananas represent the reward and the crocodile represents the risk. The blue path is a low risk-low return decision, while th

Researchers identify and manipulate neural circuits for risk/reward decision-making in primates

by Spyros Goulas, Institute for the Advanced Study of Human Biology (ASHBI)Bananas represent the reward and the crocodile represents the risk. The blue path is a low risk-low return decision, while th
Study shows web app effective in determining access to statins without a prescription

Study shows web app effective in determining access to statins without a prescription

byAmerican College of CardiologyCredit: Pixabay/CC0 Public DomainUsing a web application to qualify individuals for treatment with a non-prescription statin closely matched the results of clinic

Study shows web app effective in determining access to statins without a prescription

byAmerican College of CardiologyCredit: Pixabay/CC0 Public DomainUsing a web application to qualify individuals for treatment with a non-prescription statin closely matched the results of clinic
A new gene-editing system tackles complex diseases

A new gene-editing system tackles complex diseases

by Michelle Franklin,University of California - San DiegoA schematic overview of multiplexed orthogonal base editing. Credit:Nature Biotechnology(2024). DOI: 10.1038/s41587-024-02240

A new gene-editing system tackles complex diseases

by Michelle Franklin,University of California - San DiegoA schematic overview of multiplexed orthogonal base editing. Credit:Nature Biotechnology(2024). DOI: 10.1038/s41587-024-02240
Gut Microbiome Changes as Early Indicators of Rheumatoid Arthritis Development

Gut Microbiome Changes as Early Indicators of Rheumatoid Arthritis Development

The intricate relationship between the gut microbiome and rheumatoid arthritis (RA) has become a significant area of research, with recent studies providing valuable insights into how gut bacteria might influence the onset and progression of this chronic

Gut Microbiome Changes as Early Indicators of Rheumatoid Arthritis Development

The intricate relationship between the gut microbiome and rheumatoid arthritis (RA) has become a significant area of research, with recent studies providing valuable insights into how gut bacteria might influence the onset and progression of this chronic
Testing found recalled medicine can have a deadly bacterial contamination

Testing found recalled medicine can have a deadly bacterial contamination

by David J. Neal, Miami HeraldCredit: Pixabay/CC0 Public DomainA drug used to treat a form of pneumonia has been recalled after testing found it might be as deadly as the infection it's supposed t

Testing found recalled medicine can have a deadly bacterial contamination

by David J. Neal, Miami HeraldCredit: Pixabay/CC0 Public DomainA drug used to treat a form of pneumonia has been recalled after testing found it might be as deadly as the infection it's supposed t
Researchers develop innovative and flexible method to study immune cell capabilities

Researchers develop innovative and flexible method to study immune cell capabilities

byNational University of SingaporeSchematic of PAINTKiller assay. a, Preparation of affinity matrix on effector cells. Effector cells were first labeled with anti-CD45 conjugated with streptavid

Researchers develop innovative and flexible method to study immune cell capabilities

byNational University of SingaporeSchematic of PAINTKiller assay. a, Preparation of affinity matrix on effector cells. Effector cells were first labeled with anti-CD45 conjugated with streptavid