Autophagy-tethering compounds may open new directions in targeted drug discovery

byScience China Press(A) Molecular glue ATTECs are targeting polyQ proteins in neurodegenerative disorders. (B) Bifunctional ATTECs targeting oncoprotein BRD4. (C) Bifunctional ATTECs targeting

Updated on: March 28,2024

Autophagy-tethering compounds may open new directions in targeted drug discovery

byScience China Press(A) Molecular glue ATTECs are targeting polyQ proteins in neurodegenerative disorders. (B) Bifunctional ATTECs targeting oncoprotein BRD4. (C) Bifunctional ATTECs targeting

Updated on:March 28,2024

COVID-19 viral load rebound can occur after VV116, nirmatrelvir-ritonavir

by Elana GotkineFor patients with mild-to-moderate COVID-19, viral load rebound and symptom rebound can occur after a standard five-day course of treatment with VV116 or nirmatrelvir-ritonavir, accord

Updated on: March 28,2024

COVID-19 viral load rebound can occur after VV116, nirmatrelvir-ritonavir

by Elana GotkineFor patients with mild-to-moderate COVID-19, viral load rebound and symptom rebound can occur after a standard five-day course of treatment with VV116 or nirmatrelvir-ritonavir, accord

Updated on:March 28,2024

Lifespan increases in mice when specific brain cells are activated, study finds

by Julia Evangelou Strait,Washington University School of MedicineWith age, the researchers found that the protein Ppp1r17 tends to leave the nucleus of the neurons, and when that happens, the n

Updated on: January 09,2024

Lifespan increases in mice when specific brain cells are activated, study finds

by Julia Evangelou Strait,Washington University School of MedicineWith age, the researchers found that the protein Ppp1r17 tends to leave the nucleus of the neurons, and when that happens, the n

Updated on:January 09,2024

Organs-on-chips provide insights into molecular mechanisms of disease, facilitate design of newer treatment strategies

by Xia & He Publishing Inc.An illustration of organ-on-chip simulating the biological microenvironment. Credit:Journal of Exploratory Research in Pharmacology(2024). DOI: 10.14218/JERP

Updated on: July 23,2024

Organs-on-chips provide insights into molecular mechanisms of disease, facilitate design of newer treatment strategies

by Xia & He Publishing Inc.An illustration of organ-on-chip simulating the biological microenvironment. Credit:Journal of Exploratory Research in Pharmacology(2024). DOI: 10.14218/JERP

Updated on:July 23,2024

FDA asked to consider party drug MDMA as treatment for PTSD

by Robin FosterA California company has asked the U.S. Food and Drug Administration to approve MDMA, the active ingredient in party drugs like molly and ecstasy, as a treatment for post-traumatic stre

Updated on: January 26,2024

FDA asked to consider party drug MDMA as treatment for PTSD

by Robin FosterA California company has asked the U.S. Food and Drug Administration to approve MDMA, the active ingredient in party drugs like molly and ecstasy, as a treatment for post-traumatic stre

Updated on:January 26,2024

West Virginia city once battered by opioid overdoses confronts 'fourth wave'

by Taylor Sisk, KFF Health NewsCredit: CC0 Public DomainFrom 2006 through 2014, more than 81 million painkiller pills were shipped to this city and surrounding rural Cabell County.The arrival of presc

Updated on: March 28,2024

West Virginia city once battered by opioid overdoses confronts 'fourth wave'

by Taylor Sisk, KFF Health NewsCredit: CC0 Public DomainFrom 2006 through 2014, more than 81 million painkiller pills were shipped to this city and surrounding rural Cabell County.The arrival of presc

Updated on:March 28,2024

Tracking ticks in Georgia to help monitor emerging diseases

by Carol Clark,Emory UniversityMapping the lone star tick is another step in a comprehensive Emory project to track and monitor the array of tick species in Georgia and the diseases that they ca

Updated on: April 06,2024

Tracking ticks in Georgia to help monitor emerging diseases

by Carol Clark,Emory UniversityMapping the lone star tick is another step in a comprehensive Emory project to track and monitor the array of tick species in Georgia and the diseases that they ca

Updated on:April 06,2024

Siris tree leaves hold promise for stopping spread of breast cancer cells, say researchers

by University of SharjahAlbizia lebbeck—Shirish/Siris Tree. Credit: Wikimedia Commons,CC BY-SA 4.0Albizia lebbeck is the scientific name of the siris tree, which may hold the promise of wor

Updated on: April 06,2024

Siris tree leaves hold promise for stopping spread of breast cancer cells, say researchers

by University of SharjahAlbizia lebbeck—Shirish/Siris Tree. Credit: Wikimedia Commons,CC BY-SA 4.0Albizia lebbeck is the scientific name of the siris tree, which may hold the promise of wor

Updated on:April 06,2024

A new gene-editing system tackles complex diseases

by Michelle Franklin,University of California - San DiegoA schematic overview of multiplexed orthogonal base editing. Credit:Nature Biotechnology(2024). DOI: 10.1038/s41587-024-02240

Updated on: May 30,2024

A new gene-editing system tackles complex diseases

by Michelle Franklin,University of California - San DiegoA schematic overview of multiplexed orthogonal base editing. Credit:Nature Biotechnology(2024). DOI: 10.1038/s41587-024-02240

Updated on:May 30,2024

US company withdraws ALS drug after it fails in trial

An MRI with increased signal in the posterior part of the internal capsule which can be tracked to the motor cortex consistent with the diagnosis of ALS. Credit: Frank Gaillard/WikipediaAmylyx Pharmac

Updated on: April 06,2024

US company withdraws ALS drug after it fails in trial

An MRI with increased signal in the posterior part of the internal capsule which can be tracked to the motor cortex consistent with the diagnosis of ALS. Credit: Frank Gaillard/WikipediaAmylyx Pharmac

Updated on:April 06,2024

Researchers report encouraging first evidence of effective new gene therapy to treat multiple sulfatase deficiency

byChildren's Hospital of PhiladelphiaCredit:Molecular Therapy(2024). DOI: 10.1016/j.ymthe.2024.08.015Researchers from Children's Hospital of Philadelphia (CHOP) have tested a

Updated on: September 14,2024

Researchers report encouraging first evidence of effective new gene therapy to treat multiple sulfatase deficiency

byChildren's Hospital of PhiladelphiaCredit:Molecular Therapy(2024). DOI: 10.1016/j.ymthe.2024.08.015Researchers from Children's Hospital of Philadelphia (CHOP) have tested a

Updated on:September 14,2024

Preoperative GLP-1 agonist use does not increase aspiration

by Elana GotkinePreoperative glucagon-like peptide-1 (GLP-1) agonist use does not increase the risk for aspiration or subsequent pneumonia in patients undergoing various surgical procedures, according

Updated on: April 28,2024

Preoperative GLP-1 agonist use does not increase aspiration

by Elana GotkinePreoperative glucagon-like peptide-1 (GLP-1) agonist use does not increase the risk for aspiration or subsequent pneumonia in patients undergoing various surgical procedures, according

Updated on:April 28,2024