Drug development advances in beneficial loss-of-function mutation targets validated by human genetics

by Sichuan International Medical Exchange and Promotion AssociationTargets primarily include PCSK9, ANGPTL3, HSD17B13, KHK, ASGR1, GPR75, CIDEB, and INHBE. Drug types primarily include small molecules

Updated on: March 28,2024

Drug development advances in beneficial loss-of-function mutation targets validated by human genetics

by Sichuan International Medical Exchange and Promotion AssociationTargets primarily include PCSK9, ANGPTL3, HSD17B13, KHK, ASGR1, GPR75, CIDEB, and INHBE. Drug types primarily include small molecules

Updated on:March 28,2024

Five-day antibiotic course noninferior for pediatric febrile UTI

by Elana GotkineFor young children with febrile urinary tract infection (fUTI), a five-day amoxicillin-clavulanate course is noninferior to a 10-day course for recurrence of UTI within 30 days after c

Updated on: January 26,2024

Five-day antibiotic course noninferior for pediatric febrile UTI

by Elana GotkineFor young children with febrile urinary tract infection (fUTI), a five-day amoxicillin-clavulanate course is noninferior to a 10-day course for recurrence of UTI within 30 days after c

Updated on:January 26,2024

A new vision for AAV-delivered gene therapies

by Benjamin Boettner,Harvard UniversityAAVs with TLR9-inhibitory sequences incorporated into their genomes allowed significantly higher expression of a linked fluorescent reporter gene in the mo

Updated on: April 02,2024

A new vision for AAV-delivered gene therapies

by Benjamin Boettner,Harvard UniversityAAVs with TLR9-inhibitory sequences incorporated into their genomes allowed significantly higher expression of a linked fluorescent reporter gene in the mo

Updated on:April 02,2024

Study confirms how RNA chemical modifications benefit HIV-1

by Emily Caldwell,The Ohio State UniversityHIV-1 Virus. Credit: J Roberto Trujillo/WikipediaA chemical modification in the HIV-1 RNA genome whose function has been a matter of scientific debate

Updated on: April 28,2024

Study confirms how RNA chemical modifications benefit HIV-1

by Emily Caldwell,The Ohio State UniversityHIV-1 Virus. Credit: J Roberto Trujillo/WikipediaA chemical modification in the HIV-1 RNA genome whose function has been a matter of scientific debate

Updated on:April 28,2024

Prolonged use of certain hormone drugs linked to increased brain tumor risk

by British Medical JournalMeningiomas are graded by microscopic appearance, rate of growth and tendency to invade other tissues. Credit: National Cancer InstituteProlonged use of certain progesto

Updated on: March 30,2024

Prolonged use of certain hormone drugs linked to increased brain tumor risk

by British Medical JournalMeningiomas are graded by microscopic appearance, rate of growth and tendency to invade other tissues. Credit: National Cancer InstituteProlonged use of certain progesto

Updated on:March 30,2024

Researchers help design easy-to-open, child-resistant medicine bottle

by Abby Robinson,Georgia Institute of TechnologyEquipment used by Georgia Tech Research Institute (GTRI) product design researchers measures the forces required to open prescription medicine con

Updated on: March 24,2024

Researchers help design easy-to-open, child-resistant medicine bottle

by Abby Robinson,Georgia Institute of TechnologyEquipment used by Georgia Tech Research Institute (GTRI) product design researchers measures the forces required to open prescription medicine con

Updated on:March 24,2024

Dicer enzyme cuts down on fats

by Ludwig Maximilian University of MunichDicer knockout in macrophages (right) accelerates atherosclerosis. Credit: Yuanyuan Wei, LMUThe enzyme Dicer cleaves long precursors into short RNA molecu

Updated on: April 12,2024

Dicer enzyme cuts down on fats

by Ludwig Maximilian University of MunichDicer knockout in macrophages (right) accelerates atherosclerosis. Credit: Yuanyuan Wei, LMUThe enzyme Dicer cleaves long precursors into short RNA molecu

Updated on:April 12,2024

Many antibiotic courses for common infections not in line with guidelines

by British Medical JournalCredit: CC0 Public DomainMany antibiotic courses prescribed for common infections treated in English primary care (general practices and community services) exceed the r

Updated on: March 06,2024

Many antibiotic courses for common infections not in line with guidelines

by British Medical JournalCredit: CC0 Public DomainMany antibiotic courses prescribed for common infections treated in English primary care (general practices and community services) exceed the r

Updated on:March 06,2024

Researchers develop framework to identify molecules responsible for chemotherapy resistance

JANUARY 18, 2024byKarolinska InstitutetCredit:iScience(2024). https://www.cell.com/iscience/fulltext/S2589-0042(24)00128-7Researchers at Karolinska Institutet and SciLifeLab demonstr

Updated on: March 29,2024

Researchers develop framework to identify molecules responsible for chemotherapy resistance

JANUARY 18, 2024byKarolinska InstitutetCredit:iScience(2024). https://www.cell.com/iscience/fulltext/S2589-0042(24)00128-7Researchers at Karolinska Institutet and SciLifeLab demonstr

Updated on:March 29,2024

Poison center calls related to injected weight-loss drugs up 1,500%

by Nancy Clanton, The Atlanta Journal-ConstitutionCredit: Pixabay/CC0 Public DomainAmerica's Poison Centers reported nearly 3,000 calls this year involving the weight loss drug semaglutide—a 15-fo

Updated on: January 26,2024

Poison center calls related to injected weight-loss drugs up 1,500%

by Nancy Clanton, The Atlanta Journal-ConstitutionCredit: Pixabay/CC0 Public DomainAmerica's Poison Centers reported nearly 3,000 calls this year involving the weight loss drug semaglutide—a 15-fo

Updated on:January 26,2024

Researchers present playbook of best practices for cancer team science in the modern era

by Break Through CancerThe Hallmarks of Cancer Collaboration. Based on Hanahan and Weinberg's seminal "Hallmarks of Cancer," this illustration proposes six Hallmarks of Cancer Collaborat

Updated on: April 06,2024

Researchers present playbook of best practices for cancer team science in the modern era

by Break Through CancerThe Hallmarks of Cancer Collaboration. Based on Hanahan and Weinberg's seminal "Hallmarks of Cancer," this illustration proposes six Hallmarks of Cancer Collaborat

Updated on:April 06,2024

Researchers develop a new toolkit of fruit flies to study Zika virus

FEBRUARY 28, 2024byTexas Children's HospitalZIKV proteins cause scorable phenotypes upon overexpression in Drosophila. (A) Graphical diagram of the Zika virus (ZIKV) polyprotein, which conta

Updated on: March 29,2024

Researchers develop a new toolkit of fruit flies to study Zika virus

FEBRUARY 28, 2024byTexas Children's HospitalZIKV proteins cause scorable phenotypes upon overexpression in Drosophila. (A) Graphical diagram of the Zika virus (ZIKV) polyprotein, which conta

Updated on:March 29,2024