Organs-on-chips provide insights into molecular mechanisms of disease, facilitate design of newer treatment strategies

by Xia & He Publishing Inc.An illustration of organ-on-chip simulating the biological microenvironment. Credit:Journal of Exploratory Research in Pharmacology(2024). DOI: 10.14218/JERP

Updated on: July 23,2024 0

Organs-on-chips provide insights into molecular mechanisms of disease, facilitate design of newer treatment strategies

by Xia & He Publishing Inc.An illustration of organ-on-chip simulating the biological microenvironment. Credit:Journal of Exploratory Research in Pharmacology(2024). DOI: 10.14218/JERP

Updated on:July 23,2024 0

Circuit-specific gene therapy brings new hope for treatment of Parkinson's disease

byChinese Academy of SciencesRetrograde AAV selectively targets D1-MSNs and rescues parkinsonian symptoms with chemogenetic modulation. Credit: SIATResearchers from the Shenzhen Institute of Adv

Updated on: March 14,2024 16

Circuit-specific gene therapy brings new hope for treatment of Parkinson's disease

byChinese Academy of SciencesRetrograde AAV selectively targets D1-MSNs and rescues parkinsonian symptoms with chemogenetic modulation. Credit: SIATResearchers from the Shenzhen Institute of Adv

Updated on:March 14,2024 16

Scientists develop an agent capable of selectively inhibiting the body's stress response

JANUARY 22, 2024by Daniel Meierhans,ETH ZurichThe DEGs we identified upon 2 h, and 18 h of DEX treatments in A549 cells align with the other existing RNAseq and ChIP-seq datasets. Credit:N

Updated on: March 25,2024 6

Scientists develop an agent capable of selectively inhibiting the body's stress response

JANUARY 22, 2024by Daniel Meierhans,ETH ZurichThe DEGs we identified upon 2 h, and 18 h of DEX treatments in A549 cells align with the other existing RNAseq and ChIP-seq datasets. Credit:N

Updated on:March 25,2024 6

Common human gene mutations linked to a range of health conditions

byUniversity of GlasgowPCA plots of principal components calculated from Affymetrix genotype data from the 10,179 participants that had UK Biobank PC1 > 100 and PC2 > 0. (a) Participants w

Updated on: April 26,2024 0

Common human gene mutations linked to a range of health conditions

byUniversity of GlasgowPCA plots of principal components calculated from Affymetrix genotype data from the 10,179 participants that had UK Biobank PC1 > 100 and PC2 > 0. (a) Participants w

Updated on:April 26,2024 0

New therapeutic targets for Alzheimer's discovered in spinal fluid

Updated on: November 21,2024 0

New therapeutic targets for Alzheimer's discovered in spinal fluid

Updated on:November 21,2024 0

Researchers identify promising protein candidate for metabolic disease treatment

byUniversity of SaskatchewanHepG2/C3A cells express NUCB1/NLP and NUCB2/NESF-1. Credit:Communications Biology(2024). DOI: 10.1038/s42003-024-06314-2University of Saskatchewan (USask)

Updated on: May 30,2024 0

Researchers identify promising protein candidate for metabolic disease treatment

byUniversity of SaskatchewanHepG2/C3A cells express NUCB1/NLP and NUCB2/NESF-1. Credit:Communications Biology(2024). DOI: 10.1038/s42003-024-06314-2University of Saskatchewan (USask)

Updated on:May 30,2024 0

Study eases concern at antipsychotics use in pregnancy

byUniversity of New South WalesCrude and propensity score-weighted cumulative incidence (with 95% confidence intervals) for composite neurodevelopmental outcome from age 3–19 years in children o

Updated on: March 28,2024 0

Study eases concern at antipsychotics use in pregnancy

byUniversity of New South WalesCrude and propensity score-weighted cumulative incidence (with 95% confidence intervals) for composite neurodevelopmental outcome from age 3–19 years in children o

Updated on:March 28,2024 0

Human cells building 'molecular highways' captured for first time

FEBRUARY 1, 2024byCenter for Genomic Regulationγ-TuRC starting the nucleation process (left) vs. γ-TuRC closing (right). Once closed, thhe foundation is set and tubulins can be added to make the

Updated on: March 25,2024 8

Human cells building 'molecular highways' captured for first time

FEBRUARY 1, 2024byCenter for Genomic Regulationγ-TuRC starting the nucleation process (left) vs. γ-TuRC closing (right). Once closed, thhe foundation is set and tubulins can be added to make the

Updated on:March 25,2024 8

Trials shows bimekizumab response durable at four years for moderate-to-severe psoriasis

by Tina BrownPatients with psoriasis treated with bimekizumab rapidly achieve high levels of clinical and health-related quality-of-life responses that are durable at four years, according to research

Updated on: March 28,2024 0

Trials shows bimekizumab response durable at four years for moderate-to-severe psoriasis

by Tina BrownPatients with psoriasis treated with bimekizumab rapidly achieve high levels of clinical and health-related quality-of-life responses that are durable at four years, according to research

Updated on:March 28,2024 0

First clinical trial of vosoritide for children with hypochondroplasia shows increased growth

byChildren's National HospitalStanding height SDS. Credit:eClinicalMedicine(2024). DOI: 10.1016/j.eclinm.2024.102591Vosoritide's first global Phase II study showed an average

Updated on: April 28,2024 0

First clinical trial of vosoritide for children with hypochondroplasia shows increased growth

byChildren's National HospitalStanding height SDS. Credit:eClinicalMedicine(2024). DOI: 10.1016/j.eclinm.2024.102591Vosoritide's first global Phase II study showed an average

Updated on:April 28,2024 0

Medicare doesn't cover obesity drugs, but 76% of older adults think it should: Poll

byUniversity of MichiganCredit: Pixabay/CC0 Public DomainThe vast majority of older adults—83%—think health insurers should cover medications that can help people with obesity manage their weigh

Updated on: January 26,2024 16

Medicare doesn't cover obesity drugs, but 76% of older adults think it should: Poll

byUniversity of MichiganCredit: Pixabay/CC0 Public DomainThe vast majority of older adults—83%—think health insurers should cover medications that can help people with obesity manage their weigh

Updated on:January 26,2024 16

Better cancer trials could be around the corner

by Cold Spring Harbor LaboratoryCredit: Pixabay/CC0 Public DomainCold Spring Harbor Laboratory Associate Professor and Cancer Center member Tobias Janowitz led aCOVID-19 clinical trial&nbsp

Updated on: March 30,2024 18

Better cancer trials could be around the corner

by Cold Spring Harbor LaboratoryCredit: Pixabay/CC0 Public DomainCold Spring Harbor Laboratory Associate Professor and Cancer Center member Tobias Janowitz led aCOVID-19 clinical trial&nbsp

Updated on:March 30,2024 18