Exploring the biology of 'double positive' T cells

byLudwig Cancer ResearchCredit: CC0 Public DomainThe molecular markers CD4 and CD8—defining helper T cells and killer T cells, respectively—were once considered mutually exclusive. But "dou

Updated on: January 07,2024 25

Exploring the biology of 'double positive' T cells

byLudwig Cancer ResearchCredit: CC0 Public DomainThe molecular markers CD4 and CD8—defining helper T cells and killer T cells, respectively—were once considered mutually exclusive. But "dou

Updated on:January 07,2024 25

Study reports progress in long-term protection against ovarian cancer tumors

byWayne State UniversityCharacterization of immune response during ovarian tumor progression. mCherry+ TKO mouse ovarian cancer cells were injected i.p. in C57BL/6 immunocompetent mice (n=50) or

Updated on: January 26,2024 20

Study reports progress in long-term protection against ovarian cancer tumors

byWayne State UniversityCharacterization of immune response during ovarian tumor progression. mCherry+ TKO mouse ovarian cancer cells were injected i.p. in C57BL/6 immunocompetent mice (n=50) or

Updated on:January 26,2024 20

Scientists develop first bone marrow model that supports human stem cells

byUniversity of GlasgowSchematic of the bone marrow (BM) niche microenvironment. Credit:Nature Communications(2024). DOI: 10.1038/s41467-024-50054-0Scientists have created the first

Updated on: August 03,2024 0

Scientists develop first bone marrow model that supports human stem cells

byUniversity of GlasgowSchematic of the bone marrow (BM) niche microenvironment. Credit:Nature Communications(2024). DOI: 10.1038/s41467-024-50054-0Scientists have created the first

Updated on:August 03,2024 0

Race, income can determine blood cancer outcomes, studies show

by Ernie MundellIf someone is stricken with a blood cancer or life-threatening clot, they'll probably fare better if they are white and wealthy, three new studies show.The ongoing impact of patien

Updated on: January 22,2024 15

Race, income can determine blood cancer outcomes, studies show

by Ernie MundellIf someone is stricken with a blood cancer or life-threatening clot, they'll probably fare better if they are white and wealthy, three new studies show.The ongoing impact of patien

Updated on:January 22,2024 15

Cancer therapy bexmarilimab awakens immune cells to attack tumors that have avoided detection, research finds

byUniversity of TurkuThe image shows cancer cells and macrophage immune cells. The macrophages are depicted in red whereas the cancer cells are the white-grey spots. The nuclei are shown in blue

Updated on: January 26,2024 15

Cancer therapy bexmarilimab awakens immune cells to attack tumors that have avoided detection, research finds

byUniversity of TurkuThe image shows cancer cells and macrophage immune cells. The macrophages are depicted in red whereas the cancer cells are the white-grey spots. The nuclei are shown in blue

Updated on:January 26,2024 15

CARM1 drives triple-negative breast cancer progression by coordinating with HIF1A: Study

by Higher Education PressCoactivator-associated arginine methyltransferase 1 (CARM1) was recruited by hypoxia-inducible factor 1 subunit alpha (HIF1A) to form a complex and transactivate CDK4 and HIF1

Updated on: July 09,2024 0

CARM1 drives triple-negative breast cancer progression by coordinating with HIF1A: Study

by Higher Education PressCoactivator-associated arginine methyltransferase 1 (CARM1) was recruited by hypoxia-inducible factor 1 subunit alpha (HIF1A) to form a complex and transactivate CDK4 and HIF1

Updated on:July 09,2024 0

Improving CAR-T cell therapy for solid tumors through inhibition of conventional signaling pathway

byNational University of SingaporeGraphical Abstract. Credit:Cell Reports Medicine(2023). DOI: 10.1016/j.xcrm.2023.100917Chimeric Antigen Receptor-expressing T cell (CAR-T) therapy i

Updated on: January 07,2024 10

Improving CAR-T cell therapy for solid tumors through inhibition of conventional signaling pathway

byNational University of SingaporeGraphical Abstract. Credit:Cell Reports Medicine(2023). DOI: 10.1016/j.xcrm.2023.100917Chimeric Antigen Receptor-expressing T cell (CAR-T) therapy i

Updated on:January 07,2024 10

Supercharging CAR-T cells for cancer treatment

byEcole Polytechnique Federale de LausanneIL-10-expressing CAR T cells counter dysfunction in tumors.a, Schematic depicting the HER2 CAR and IL-10 HER2 CAR constructs; scFv, single-chain v

Updated on: January 26,2024 16

Supercharging CAR-T cells for cancer treatment

byEcole Polytechnique Federale de LausanneIL-10-expressing CAR T cells counter dysfunction in tumors.a, Schematic depicting the HER2 CAR and IL-10 HER2 CAR constructs; scFv, single-chain v

Updated on:January 26,2024 16

Natural compounds derived from soy and other plants found to reduce breast cancer recurrence and improve survival

JANUARY 10, 2024Natural compounds derived from soy and other plants found to reduce breast cancer recurrence and improve survivalbyJohns Hopkins University School of MedicineFlow diagram of the

Updated on: March 15,2024 11

Natural compounds derived from soy and other plants found to reduce breast cancer recurrence and improve survival

JANUARY 10, 2024Natural compounds derived from soy and other plants found to reduce breast cancer recurrence and improve survivalbyJohns Hopkins University School of MedicineFlow diagram of the

Updated on:March 15,2024 11

A new therapeutic target turns the immune system against lymphoma

by Ecole Polytechnique Federale de LausanneCredit: CC0 Public DomainNon-Hodgkin's lymphoma (NHL) is a group of cancers that originate in the lymph nodes and affect white blood cells of the im

Updated on: March 25,2024 17

A new therapeutic target turns the immune system against lymphoma

by Ecole Polytechnique Federale de LausanneCredit: CC0 Public DomainNon-Hodgkin's lymphoma (NHL) is a group of cancers that originate in the lymph nodes and affect white blood cells of the im

Updated on:March 25,2024 17

Study shows promising safety, patient outcomes data for MRI-guided adaptive radiation therapy to treat pancreatic cancer

by Henry Ford HealthA ViewRay MRIdian system at Henry Ford Health. Credit: Henry Ford HealthFindings from a recent prospective study show promising safety and patient outcomes data for locally advance

Updated on: January 30,2024 16

Study shows promising safety, patient outcomes data for MRI-guided adaptive radiation therapy to treat pancreatic cancer

by Henry Ford HealthA ViewRay MRIdian system at Henry Ford Health. Credit: Henry Ford HealthFindings from a recent prospective study show promising safety and patient outcomes data for locally advance

Updated on:January 30,2024 16

For cancer, a biopharmaceutical company and UC San Diego test another kind of immune cell

by Bradley J. Fikes, The San Diego Union-TribuneWhen the U.S. Food and Drug Administration approved the first cell-based gene therapies for cancer in 2017, advanced malignancies once seen as terminal

Updated on: December 18,2023 23

For cancer, a biopharmaceutical company and UC San Diego test another kind of immune cell

by Bradley J. Fikes, The San Diego Union-TribuneWhen the U.S. Food and Drug Administration approved the first cell-based gene therapies for cancer in 2017, advanced malignancies once seen as terminal

Updated on:December 18,2023 23