Method that uses combination of immune cells could provide clearer prognoses

by Elin Bäckström,Swedish Research CouncilPrognostic value of CD8+T cells and CD68+CD163+macrophages revealed by comprehensive characterization of immune cell subsets in 286 therapy-

Updated on: January 04,2024 9

Method that uses combination of immune cells could provide clearer prognoses

by Elin Bäckström,Swedish Research CouncilPrognostic value of CD8+T cells and CD68+CD163+macrophages revealed by comprehensive characterization of immune cell subsets in 286 therapy-

Updated on:January 04,2024 9

Using mathematical modeling and dynamic biomarkers to characterize metastatic disease during adaptive therapy

byH. Lee Moffitt Cancer Center & Research InstituteMathematical model overview and design. A, Simulated treatment trajectory. During the seeding/growth phase, metastases are seeded and grown

Updated on: January 04,2024 8

Using mathematical modeling and dynamic biomarkers to characterize metastatic disease during adaptive therapy

byH. Lee Moffitt Cancer Center & Research InstituteMathematical model overview and design. A, Simulated treatment trajectory. During the seeding/growth phase, metastases are seeded and grown

Updated on:January 04,2024 8

Research into use of diabetes medication for treatment of metastatic prostate cancer

byMedical University of ViennaCredit: AI-generated imagePatients with localized prostate cancer have a good chance of survival, but mortality rates among those with advanced, metastatic forms of

Updated on: January 04,2024 9

Research into use of diabetes medication for treatment of metastatic prostate cancer

byMedical University of ViennaCredit: AI-generated imagePatients with localized prostate cancer have a good chance of survival, but mortality rates among those with advanced, metastatic forms of

Updated on:January 04,2024 9

Customizing T cell-based immunotherapies using new 'SNAPtag' technology

byUniversity of PittsburghUniversal adaptor SNAP-CAR and SNAP-synNotch receptor function. a A benzylguanine motif (BG) is chemically conjugated to an antibody using a benzylguanine NHS ester. Th

Updated on: January 04,2024 12

Customizing T cell-based immunotherapies using new 'SNAPtag' technology

byUniversity of PittsburghUniversal adaptor SNAP-CAR and SNAP-synNotch receptor function. a A benzylguanine motif (BG) is chemically conjugated to an antibody using a benzylguanine NHS ester. Th

Updated on:January 04,2024 12

New study using novel approach for glioblastoma treatment shows promising results, extending survival

byUniversity Health NetworkAn illustration of oncolytic virus and an anti-PD-1 antibody working together to defeat cancer cells. Credit: Tal BavliA new international study published inNatu

Updated on: January 04,2024 9

New study using novel approach for glioblastoma treatment shows promising results, extending survival

byUniversity Health NetworkAn illustration of oncolytic virus and an anti-PD-1 antibody working together to defeat cancer cells. Credit: Tal BavliA new international study published inNatu

Updated on:January 04,2024 9

Normalizing tumor blood vessels may improve immunotherapy against brain cancer

by Noah Brown,Massachusetts General HospitalAnti-VEGF treatment improves the efficacy of EGFRvIII-CAR-T cells in murine GBM tumor models. (A) Schematic representation of experimental setup to ev

Updated on: January 04,2024 9

Normalizing tumor blood vessels may improve immunotherapy against brain cancer

by Noah Brown,Massachusetts General HospitalAnti-VEGF treatment improves the efficacy of EGFRvIII-CAR-T cells in murine GBM tumor models. (A) Schematic representation of experimental setup to ev

Updated on:January 04,2024 9

World-first clinical trial with 'man's best friend' could unlock treatment breakthrough for kids with cancer

by Telethon Kids InstituteThree-year-old Bull Terrier, Maggie, is about to undergo surgery using the immunotherapy gel to treat her sarcoma. It is hoped the world-first clinical trial in dogs will be

Updated on: January 04,2024 9

World-first clinical trial with 'man's best friend' could unlock treatment breakthrough for kids with cancer

by Telethon Kids InstituteThree-year-old Bull Terrier, Maggie, is about to undergo surgery using the immunotherapy gel to treat her sarcoma. It is hoped the world-first clinical trial in dogs will be

Updated on:January 04,2024 9

World-first use of base-edited CAR T cells to treat resistant leukemia

byUniversity College LondonCredit: Unsplash/CC0 Public DomainA patient with relapsed T cell leukaemia has been given base-edited T-cells in a world-first use of a base-edited cell therapy, in a

Updated on: January 04,2024 9

World-first use of base-edited CAR T cells to treat resistant leukemia

byUniversity College LondonCredit: Unsplash/CC0 Public DomainA patient with relapsed T cell leukaemia has been given base-edited T-cells in a world-first use of a base-edited cell therapy, in a

Updated on:January 04,2024 9

Inhibition of prmt5 by repurposing market drugs: A fresh therapeutic pathway for cancer treatment

by TranSpreadDevelopment of AlphaLISA HTS screen to identify specific PRMT5 inhibitors. (A) Principle of AlphaLISA technique adapted to HTS. Biotinylated histone H4 (a well-known PRMT5 substrate) was

Updated on: January 04,2024 9

Inhibition of prmt5 by repurposing market drugs: A fresh therapeutic pathway for cancer treatment

by TranSpreadDevelopment of AlphaLISA HTS screen to identify specific PRMT5 inhibitors. (A) Principle of AlphaLISA technique adapted to HTS. Biotinylated histone H4 (a well-known PRMT5 substrate) was

Updated on:January 04,2024 9

Chemotherapy before surgery cuts risk of colon cancer returning, trial finds

byCancer Research UKCredit: CC0 Public DomainGiving colon cancer patients chemotherapy before surgery cuts their risk of the disease coming back, according to the results of a Cancer Research UK

Updated on: January 04,2024 6

Chemotherapy before surgery cuts risk of colon cancer returning, trial finds

byCancer Research UKCredit: CC0 Public DomainGiving colon cancer patients chemotherapy before surgery cuts their risk of the disease coming back, according to the results of a Cancer Research UK

Updated on:January 04,2024 6

Trial finds adding immune modulator to targeted therapy does not improve survival in difficult-to-treat thyroid cancer

byUniversity of Chicago Medical CenterCredit: Pixabay/CC0 Public DomainResults of a multicenter phase II clinical trial led by the University of Chicago Medicine Comprehensive Cancer Center show

Updated on: January 04,2024 10

Trial finds adding immune modulator to targeted therapy does not improve survival in difficult-to-treat thyroid cancer

byUniversity of Chicago Medical CenterCredit: Pixabay/CC0 Public DomainResults of a multicenter phase II clinical trial led by the University of Chicago Medicine Comprehensive Cancer Center show

Updated on:January 04,2024 10

Trial finds that adagrasib demonstrates durable clinical activity in patients with KRAS-G12C mutations

by International Association for the Study of Lung CancerCredit: Pixabay/CC0 Public DomainThe oral, selective KRAS G12C inhibitor KRAS-G12C inhibitor adagrasib demonstrated durable clinical activity,

Updated on: January 04,2024 8

Trial finds that adagrasib demonstrates durable clinical activity in patients with KRAS-G12C mutations

by International Association for the Study of Lung CancerCredit: Pixabay/CC0 Public DomainThe oral, selective KRAS G12C inhibitor KRAS-G12C inhibitor adagrasib demonstrated durable clinical activity,

Updated on:January 04,2024 8