Study finds ketamine effects outlast half-life by getting trapped in NMDA receptors

by Justin Jackson , Medical XpressSingle injection of ketamine no longer causes antidepressant effects on day 3 or day 7. Credit:Nature(2023). DOI: 10.1038/s41586-023-06624-1Researchers at

Updated on: January 10,2024 5

Study finds ketamine effects outlast half-life by getting trapped in NMDA receptors

by Justin Jackson , Medical XpressSingle injection of ketamine no longer causes antidepressant effects on day 3 or day 7. Credit:Nature(2023). DOI: 10.1038/s41586-023-06624-1Researchers at

Updated on:January 10,2024 5

Plastic particles harm gut health and immunity in mice, study shows

by Zhang Nannan,Chinese Academy of SciencesEffect of PS-MNPs on the intestinal structure of mice. Representative images of H&E staining of mouse intestinal tissue. (A) Intestine of mice afte

Updated on: December 26,2023 15

Plastic particles harm gut health and immunity in mice, study shows

by Zhang Nannan,Chinese Academy of SciencesEffect of PS-MNPs on the intestinal structure of mice. Representative images of H&E staining of mouse intestinal tissue. (A) Intestine of mice afte

Updated on:December 26,2023 15

Chelation therapy does not improve outcomes after heart attack

byAmerican College of CardiologyCredit: Pixabay/CC0 Public DomainPeople with diabetes who had suffered a heart attack derived no clinical benefit from edetate disodium-based chelation, a therapy

Updated on: April 28,2024 0

Chelation therapy does not improve outcomes after heart attack

byAmerican College of CardiologyCredit: Pixabay/CC0 Public DomainPeople with diabetes who had suffered a heart attack derived no clinical benefit from edetate disodium-based chelation, a therapy

Updated on:April 28,2024 0

New insight into old IBD drug could improve treatments

by Jim Schnabel,Cornell UniversityGraphical Abstract. Credit:Cell Reports Medicine(2024). DOI: 10.1016/j.xcrm.2024.101431Although it is one of the oldest medications used to treat pa

Updated on: March 30,2024 13

New insight into old IBD drug could improve treatments

by Jim Schnabel,Cornell UniversityGraphical Abstract. Credit:Cell Reports Medicine(2024). DOI: 10.1016/j.xcrm.2024.101431Although it is one of the oldest medications used to treat pa

Updated on:March 30,2024 13

JAMA report outlines recommendations for evaluation and management of penicillin allergy

by Massachusetts General HospitalCredit: CC0 Public DomainWhile more than 32 million individuals in the U.S. have a documented penicillin allergy in their medical record, studies have shown that

Updated on: April 16,2024 20

JAMA report outlines recommendations for evaluation and management of penicillin allergy

by Massachusetts General HospitalCredit: CC0 Public DomainWhile more than 32 million individuals in the U.S. have a documented penicillin allergy in their medical record, studies have shown that

Updated on:April 16,2024 20

Why is Alzheimer’s disease so difficult to treat?

Updated on: September 20,2024 0

Why is Alzheimer’s disease so difficult to treat?

Updated on:September 20,2024 0

The Dawn of Spatial Medicine

For the first time spatial omics leads to a lifesaving treatment

Updated on: November 01,2024 0

The Dawn of Spatial Medicine

For the first time spatial omics leads to a lifesaving treatment

Updated on:November 01,2024 0

Anesthesia technology precisely controls unconsciousness in animal tests

byMassachusetts Institute of TechnologySchematic of the propofol-based CLAD system for control of unconsciousness in an NHP. The user sets the target level of the marker of unconsciousness (MOU)

Updated on: January 04,2024 10

Anesthesia technology precisely controls unconsciousness in animal tests

byMassachusetts Institute of TechnologySchematic of the propofol-based CLAD system for control of unconsciousness in an NHP. The user sets the target level of the marker of unconsciousness (MOU)

Updated on:January 04,2024 10

Scientists reveal new TEV-mediated αPD-L1-specific therapy resistance mechanism

by Zhejiang UniversityTEV PD-L1 competes with PD-L1 on tumor cells to bind αPD-L1.a,bMC38-EVs and PC3-EVs (1 μg) (a) or MC38 and PC3 cells (1 × 105) (b) were coincubated with the ind

Updated on: December 27,2023 12

Scientists reveal new TEV-mediated αPD-L1-specific therapy resistance mechanism

by Zhejiang UniversityTEV PD-L1 competes with PD-L1 on tumor cells to bind αPD-L1.a,bMC38-EVs and PC3-EVs (1 μg) (a) or MC38 and PC3 cells (1 × 105) (b) were coincubated with the ind

Updated on:December 27,2023 12

Exploring complement system response to adeno-associated virus vector gene therapy

by Kathryn Ryan,Mary Ann Liebert, IncCredit: CC0 Public DomainRecent clinical trials utilizing high doses of adeno-associated virus (AAV) vectors have highlighted a new challenge to AAV gene tra

Updated on: June 18,2024 5

Exploring complement system response to adeno-associated virus vector gene therapy

by Kathryn Ryan,Mary Ann Liebert, IncCredit: CC0 Public DomainRecent clinical trials utilizing high doses of adeno-associated virus (AAV) vectors have highlighted a new challenge to AAV gene tra

Updated on:June 18,2024 5

Predicting correct dosage may improve success of drug repurposing

by Sarah Small,Pennsylvania State UniversityCredit:Cell Reports Medicine(2023). DOI: 10.1016/j.xcrm.2023.101227Before a drug can be used to treat a disease, it must go through a leng

Updated on: May 16,2024 6

Predicting correct dosage may improve success of drug repurposing

by Sarah Small,Pennsylvania State UniversityCredit:Cell Reports Medicine(2023). DOI: 10.1016/j.xcrm.2023.101227Before a drug can be used to treat a disease, it must go through a leng

Updated on:May 16,2024 6

Drug candidate granted FDA orphan drug status for pancreatic cancer

by Roswell Park Comprehensive Cancer CenterCredit:Journal of Medicinal Chemistry(2023). DOI: 10.1021/acs.jmedchem.3c01589The U.S. Food and Drug Administration (FDA) has awarded Orphan Drug

Updated on: April 23,2024 14

Drug candidate granted FDA orphan drug status for pancreatic cancer

by Roswell Park Comprehensive Cancer CenterCredit:Journal of Medicinal Chemistry(2023). DOI: 10.1021/acs.jmedchem.3c01589The U.S. Food and Drug Administration (FDA) has awarded Orphan Drug

Updated on:April 23,2024 14